Pre Implantation Genetic Testing (PGT)

Ensuring the good health of your baby is our top priority.

Next Fertility has a unit specialized in reproductive genetics. Our goal is to diagnose and prevent chromosomal abnormalities and genetic diseases present in both the parents and the embryo before implantation in the maternal uterus.

Thanks to advances in assisted reproduction and genetics, we can avoid repeated miscarriages, embryo implantation problems and avoid the presence of genetic diseases in the embryo and future baby.

What is it?

Embryonic genetic diagnosis (PGT) techniques are used in assisted reproduction to detect abnormalities in the genetic material of embryos. This is a complementary technique that can be applied during in vitro fertilisation (IVF).

In this way, we avoid transferring embryos with genetic or chromosomal alterations that imply a high probability of developing a genetic disease or that present little viability to continue its evolution in the maternal uterus.

What does it consist of?

It consists of doing a biopsy of the cells of the embryo before being transferred to the uterus and studying them in the genetic diagnostic laboratory in order to identify the embryos that are carriers of a certain genetic disease.

When are they indicated?

  • Risk of transmission of an inherited genetic disease to offspring.
  • When there is a previous child, affected by an inherited disease.
  • After several implantation failures.
  • In cases of advanced maternal age.
  • Repeated abortions.

What does PGT allow?

  • Improving embryo selection. We will have information about which embryos do not have alterations and therefore are more likely to give rise to a healthy child.
  • To reduce the risk of miscarriage by preventing embryo transfer with a low probability of implantation.
  • Reducing the costs and the number of treatments, since it will not be necessary to freeze and transfer embryos with genetic alterations, since we already know that they will not be viable.

Are there different types of PGT?

1

Pre-implantation genetic test for the detection of aneuploidies (PGT-A)

It allows detecting numerical alterations, that is, if there are more or less chromosomes in the embryos. Down syndrome, for example, occurs when, instead of having two chromosomes for par 21, there are three (trisomy 21). Other chromosomal aneuploidies (a chromosome of more or less) are trisomy 18; trisomy 15; or 47 and XXY (Klinefelter syndrome).

2

Pre-implantation Genetic Test for the detection of monogenic diseases (PGT-M)

It is recommended when parents are carriers of an inherited disease. This technique can detect the alteration or mutation in a gene that causes the disease.

This test analyzes different types of inherited diseases-autosomal recessive, autosomal dominant and X-linked diseases, such as cystic fibrosis, Huntington’s disease, fragile X syndrome, hemophilia A, sickle cell anemia and Marfan disease.

3

Pre-implantation Genetic Test for the detection of structural chromosome alterations (PGT-SR)

This test detects embryos that have abnormal chromosomes due to rupture or because there is an incorrect union of segments.

These structural chromosome abnormalities are of many types: deletions, translocations, duplications, insertions, inversions, etc… and rings. The disease occurs in cases where the gene cannot be expressed correctly due to alteration in the structure of the chromosome.

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